Found the solutions from this blog http://blog.echothis.com/2009/04/02/reading-ct-scans-with-efilmltexe-on-vista/ Reading CT scans with eFilmLT.exe on Vista A bit off-topic but I thought I’d share. A friend of mine had this CT scan on CD and was having trouble reading it on his PC (sometimes it worked, sometimes not). And simply copying it to his hard disk enabled it unreadable. So I offered to debug why, and lo and behold, a quick Google search shows that lots of other people have reported similar problems (e.g., see here ). It seems that this proprietary reader (eFilmLT.exe), made by Merge Software, looks for a valid binary “DICOMDIR” file that points to the metadata for the particular scan images on the CD (e.g., the patient name, date taken, image filenames, etc.). Why this isn’t a human-readable format like XML, I have no idea. Anyway, if you have a set of images that you can’t read: copy them to your hard disk download the attached zipfile, which contains al...